‘Drivers’ and ‘Passengers’: who’s in charge?

Genome sequencing has revealed that a plethora of gene mutations can co-exist in individual cancers: thousands in some cases. Based on Darwinian theory, we assume that whilst most are irrelevant, buried in the background is a modest number of mutations (perhaps counted in single figures) that are functionally active in a way that contributes to cancer clonal development.
Institute of Cancer Research